Filtyp
In observational studies using routinely collected data, a variable with a high level of missingness or misclassification may determine whether an observation is included in the analysis. In settings where inclusion criteria are assessed after imputation, the popular multiple-imputation variance estimator proposed by Rubin (“Rubin’s rules” (RR)) is biased due to incompatibility between imputation
A growing number of studies use data before and after treatment initiation in groups exposed to different treatment strategies to estimate “causal effects” using a ratio measure called the prior event rate ratio (PERR). Here, we offer a causal interpretation for PERR and its additive scale analog, the prior event rate difference (PERD). Read the paper at https://academic.oup.com/aje/article/190/1/
https://www.lupop.lu.se/article/causal-interpretation-rate-change-methods-prior-event-rate-ratio-and-rate-difference - 2025-10-01
The coronavirus disease 2019 (COVID-19) pandemic and the coming transition to a postpandemic world where COVID-19 will likely remain as an endemic disease present a host of challenges and opportunities in epidemiologic research. Read the paper at https://academic.oup.com/aje/article/190/1/17/5874603
https://www.lupop.lu.se/article/what-now-epidemiology-wake-pandemic - 2025-10-01
Suppose that an investigator wants to estimate an association between a continuous exposure variable and an outcome, adjusting for a set of confounders. If the exposure variable suffers classical measurement error, in which the measured exposures are distributed with independent error around the true exposure, then an estimate of the covariate-adjusted exposure-outcome association may be biased. R
https://www.lupop.lu.se/article/reducing-bias-due-exposure-measurement-error-using-disease-risk-scores - 2025-10-01
In aspiring to be discerning epidemiologists, we must learn to think critically about the fundamental concepts in our field and be able to understand and apply many of the novel methods being developed today. We must also find effective ways to teach both basic and advanced topics in epidemiology to graduate students, in a manner that goes beyond simple provision of knowledge. Read the paper at ht
https://www.lupop.lu.se/article/simulation-tool-teaching-and-learning-epidemiologic-methods - 2025-10-01
Factorial Mendelian randomization is the use of genetic variants to answer questions about interactions. Although the approach has been used in applied investigations, little methodological advice is available on how to design or perform a factorial Mendelian randomization analysis. Read the paper at https://academic.oup.com/ije/article/49/4/1147/5542600?rss=1
https://www.lupop.lu.se/article/factorial-mendelian-randomization-using-genetic-variants-assess-interactions - 2025-10-01
Unmeasured confounding can bias the relationship between exposure and outcome. Sensitivity analyses generate bias-adjusted measures but these are not much used; this may change with the availability of the E-value (for evidence for causality in observational studies), appealing for its ease of calculation. Read the paper at https://academic.oup.com/ije/article/49/5/1509/5913108
https://www.lupop.lu.se/article/bias-factor-maximum-bias-and-e-value-insight-and-extended-applications - 2025-10-01
We illustrate the method and some potential choices using data from England for men diagnosed with melanoma. Various marginal measures are presented and compared. Read the paper at https://academic.oup.com/ije/article/49/5/1614/5896134
The PhD position is linked to the research project The long reach of the neighborhood: Health, education and earnings in Landskrona, Sweden, 1904-2015, funded by Handelsbankens forskningsstiftelser. The PhD student will work in this project in collaboration with other project members and will be affiliated with the Centre for Economic Demography at LUSEM (CED, www.ed.lu.se). Read more and apply he
https://www.lupop.lu.se/article/phd-position-economic-history-neighborhood-effects-over-life-course - 2025-10-01
Find out how GDPR will affect you and your research! More information, including programme, here.
https://www.lupop.lu.se/article/gdpr-event - 2025-10-01
This paper describes the multiform, wave-missing and two-method designs, including their benefits, their impact on bias and power, and other factors that must be taken into consideration when implementing them in an epidemiological study design. Read the paper at https://academic.oup.com/ije/article/49/5/1702/5827680
https://www.lupop.lu.se/article/reflection-modern-methods-planned-missing-data-designs-epidemiological-research - 2025-10-01
Hans Knutsson, lektor och programchef på Ekonomihögskolan, har använt Inspera i ett par år nu och ur ett lärarperspektiv är han mycket nöjd. Han har använt verktyget både i sal och på distans och ser framför allt positivt på alla de möjligheter som Inspera erbjuder i form av många olika frågeformat. Foto: Johan Persson och Unsplash.com – Det känns tryggt med Inspera eftersom det är ett beprövat sy
https://www.education.lu.se/artikel/lararen-om-inspera-stor-rikedom-av-frageformat - 2025-10-01
Video kan användas på olika sätt i undervisningen. Belt och Lowenthal (2021) ger en översikt av litteraturen om hur video kan användas i undervisningen och vad vi vet om hur det påverkar inlärningen. Här sammanfattas denna artikel. Foto: Nicole Geri via Unsplash.com De praktiska slutsatser författarna kommer fram till är de följande: Videoföreläsningar bör delas upp i kortare delar och de blir m
https://www.education.lu.se/artikel/att-anvanda-video-i-undervisningen - 2025-10-01
Corona och den följande nedstängingen av universitet över hela världen har betytt att vi alla behövt lära oss undervisa på distans i ett högt tempo. Pedagoger över hela världen har samlat erfarenheter och utvärderat hur det fungerat och talar ofta om samtiden som ”det nya normala” och avser då en situation där både lärare och studenter förväntar sig att undervisning tar tillvara kunskaper och färd
https://www.education.lu.se/artikel/det-nya-normala-en-litteraturoversikt - 2025-10-01
A research group from Lund Stem Cell Center aims to understand a specific type of neuron that could underlie several brain disorders including schizophrenia, epilepsy and autism, and are developing exciting new strategies to treat them. Read the full article here.
https://www.multipark.lu.se/article/restoring-neural-networks-and-understanding-brain-disorders - 2025-10-01
Researchers at Lund University in Sweden believe they have identified a gene variant that can cause cerebral small vessel disease and stroke. The study is published in Neurology Genetics. Read more about this discovery. Article in Neurology Genetics MAP3K6 Mutations in a Neurovascular Disease Causing Stroke, Cognitive Impairment, and Tremor (Neurology Genetics, February 2021)
https://www.multipark.lu.se/article/new-gene-variant-linked-stroke - 2025-10-01
Overexpression of the Parkinson-related protein, α-synuclein, leads to blood-brain barrier leakage and pericyte activation in mice. A study published in Scientific Reports identifies pericytes as potential target cells for early interventions. Parkinson’s disease is a movement disorder caused by the accumulation and aggregation of α-synuclein and degeneration of dopaminergic neurons. Disruption of
Researchers from Lund Stem Cell Center highlight the importance of controlling viral elements that reside in the genome and how their activation during development may contribute to brain disorders later in life. Around 10% of the human genome is composed of DNA sequences originating from viruses that infected our ancestors throughout the millions of years of our evolution. Under normal conditions
https://www.multipark.lu.se/article/activation-ancient-viruses-during-brain-development-causes-inflammation - 2025-10-01
During her PhD studies Shelby Shrigley has been exploring patient-specific cell replacement therapy for Parkinson's disease. Defending her PhD thesis on March 12th, here Shelby tells us about her research within the Developmental and Regenerative Neurobiology research group led by Prof. Malin Parmar and her time spent at Lund Stem Cell Center. Can you tell us about your PhD research? The main focu
https://www.multipark.lu.se/article/phd-defence-interview-shelby-shrigley - 2025-10-01
Alzheimer’s disease seems to progress faster in women than in men. The protein tau accumulates at a higher rate in women, according to research from Lund University in Sweden. The study was recently published in Brain. Over 30 million people suffer from Alzheimer’s disease worldwide, making it the most common form of dementia. Tau and beta-amyloid are two proteins known to aggregate and accumulate
https://www.multipark.lu.se/article/women-accumulate-alzheimers-related-protein-faster - 2025-10-01
